2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base) ( —— )

产品货号. M30077 CAS No. ——

2-Furoyl-LIGRLO-amide is a potent and selective protease-activated receptor 2 (PAR2) agonist.

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
100MG	获取报价	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货

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生物学信息

产品名称

2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base)
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

2-Furoyl-LIGRLO-amide is a potent and selective protease-activated receptor 2 (PAR2) agonist.
产品描述

2-Furoyl-LIGRLO-amide is a potent and selective protease-activated receptor 2 (PAR2) agonist.(In Vitro):2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is equally effective to and 10 to 25 times more potent than SLIGRLNH2 for increasing intracellular calcium in cultured human and rat PAR2-expressing cells, respectively. In bioassays of tissue PAR2 activity, measured as arterial vasodilation and hyperpolarization, 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is 10 to 300 times more potent than SLIGRL-NH2. Unlike trans-cinnamoyl-LIGRLO-NH2, 2-Furoyl-LIGRLO-amide do not cause a prominent non-PAR2-mediated contraction of murine femoral arteries.
体外实验

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体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

Proteise-activated receptor 2 (PAR2)
研究领域

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适应症

——

化学信息

CAS Number

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分子量

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分子式

——
纯度

>98% (HPLC)
溶解度

——
SMILES

——
化学全称

Sequence:{Fur-2-oyl}-Leu-Ile-Gly-Arg-Leu-{Orn}-NH2

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

McGuire JJ, et al. 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J Pharmacol Exp Ther. 2004 Jun;309(3):1124-31.

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